LOLA
07-01-2010, 09:06 PM
Cephalosporins:
They are broad-spectrum antibiotics which are used for the treatment of septicaemia, pneumonia, meningitis, biliary-tract infections, peritonitis, and urinary-tract infections.*
they act by interfering with bacterial cell wall synthesis( like penicillin)
Excretion: being principally renal
Cephalosporins penetrate the cerebrospinal fluid poorly unless the meninges are inflamed;
The principal side-effect of the cephalosporins is hypersensitivity**
Patients with a history of immediate hypersensitivity to penicillin should not receive a cephalosporin.
Antibiotic-associated colitis may occur with the use of broad-spectrum cephalosporins.
Cephalosporins have been classified as first, second, third, or fourth generation, based largely on their bacterial susceptibility patterns and resistance to β-lactamases
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*Note:
Cephalosporins are ineffective against MRSA, L. monocytogenes, Clostridium difficile, and the enterococci
**If a cephalosporin is essential in these patients because a suitable alternative antibacterial is not available, then cefixime, cefotaxime, ceftazidime, ceftriaxone, or cefuroxime can be used with caution; cefaclor, cefadroxil, cefalexin, and cefradine should be avoided…
يتبع........إن شاء الله
They are broad-spectrum antibiotics which are used for the treatment of septicaemia, pneumonia, meningitis, biliary-tract infections, peritonitis, and urinary-tract infections.*
they act by interfering with bacterial cell wall synthesis( like penicillin)
Excretion: being principally renal
Cephalosporins penetrate the cerebrospinal fluid poorly unless the meninges are inflamed;
The principal side-effect of the cephalosporins is hypersensitivity**
Patients with a history of immediate hypersensitivity to penicillin should not receive a cephalosporin.
Antibiotic-associated colitis may occur with the use of broad-spectrum cephalosporins.
Cephalosporins have been classified as first, second, third, or fourth generation, based largely on their bacterial susceptibility patterns and resistance to β-lactamases
…………………………………………………………………………………………………
*Note:
Cephalosporins are ineffective against MRSA, L. monocytogenes, Clostridium difficile, and the enterococci
**If a cephalosporin is essential in these patients because a suitable alternative antibacterial is not available, then cefixime, cefotaxime, ceftazidime, ceftriaxone, or cefuroxime can be used with caution; cefaclor, cefadroxil, cefalexin, and cefradine should be avoided…
يتبع........إن شاء الله